[NH2:1][C:2]([NH:4][C:5]([NH2:7])=[S:6])=S.CI.[CH3:10][O:11][C:12]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[C:13]=1[CH2:14][NH2:15]>CO.C(O)C>[CH3:21][O:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]([O:11][CH3:10])[C:13]=1[CH2:14][NH:15][C:2](=[NH:1])[NH:4][C:5]([NH2:7])=[S:6]2.00 g (14.8 mmol) dithiobiuret were placed in 25 ml methanol and 2.10 g (14.8 mmol) methyliodide were added at room temperature. The mixture was heated for 3 hours at reflux, then the solution was concentrated, was diluted with 25 ml of ethanol and 2.47 g (14.8 mmol) 2,6-dimethoxybenzylamine were added. The mixture was subsequently stirred again for 2 hours at reflux and subsequently for 30 minutes at 5° C. Filtration of the precipitate formed yielded 970 mg N-[[(2,6-dimethoxybenzyl)amino](imino)methyl]thiourea.
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