Sodium Hydroxide → HCID 59302986, Verbindung

HRID 448121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 448121
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[OH-].[Na+]>C1COCC1>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:12])=[O:13])=[CH:15][CH:16]=1)([CH3:23])([CH3:22])[CH3:21]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59302970HCID 59302970, Verbindung

Produkt 1

HCID 59302986HCID 59302986, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 3 M NaOH (aq)/THF (1:3) (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid as a light yellow solid: MS (ES) M+H expect 443.2, found 443.4.

Aufarbeitung

  1. customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
  2. customwas purified by preparative TLC

Quellen und Nachweise

ORD-Eintrag
ord-9588595bf72c4067b05b8f446e49b462
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481579B2

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