tert-butyl[(3S,5S)-5-(2-fluorophenyl)-1-(2-methylpropyl)-2-oxopiperidin-3-yl]carbamate → (3S,5S)-3-amino-5-(2-fluorophenyl)-1-(2-methylpropyl)piperidin-2-one

HRID 448223Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 448223
C(OC(=O)[NH:7][C@H:8]1[CH2:13][C@@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[CH2:11][N:10]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:9]1=[O:25])(C)(C)C>C(OCC)(=O)C>[NH2:7][C@H:8]1[CH2:13][C@@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[CH2:11][N:10]([CH2:21][CH:22]([CH3:23])[CH3:24])[C:9]1=[O:25]

Komponenten

3

Edukt 1

HCID 86665198tert-butyl[(3S,5S)-5-(2-fluorophenyl)-1-(2-methylpropyl)-2-oxopiperidin-3-yl]carbamate

Produkt 1

HCID 68751255(3S,5S)-3-amino-5-(2-fluorophenyl)-1-(2-methylpropyl)piperidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
23 °C

Versuchsvorschrift

A solution of tert-butyl[(3S,5S)-5-(2-fluorophenyl)-1-(2-methylpropyl)-2-oxopiperidin-3-yl]carbamate (150 mg, 0.41 mmol) in ethyl acetate (20 mL), pre-cooled to 0° C. was sparged with HCl gas for ˜1 min. The ice-bath was removed and the acidic solution was allowed to warm to 23° C. as stirring was continued for 2 h. The mixture was then concentrated to dryness to afford the title compound as a hydrochloride salt. MS: m/z=265.1 (M+1).

Aufarbeitung

  1. customwas sparged with HCl gas for ˜1 min
  2. customThe ice-bath was removed
  3. concentrationThe mixture was then concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c95aba0fe373462a990f3a95edf1548e
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481556B2

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