(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one → (R)-8-cyclopentyl-7-ethyl-2-(2-(5-fluoropyridin-2-yl)-1H-imidazol-1-yl)-5-methyl-7,8-dihydropteridin-6(5H)-one
Reaktionsgleichung
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[C:4]=2[N:3]=1.[F:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[NH:29][CH:30]=[CH:31][N:32]=2)=[N:26][CH:27]=1>>[CH:16]1([N:5]2[C:4]3[N:3]=[C:2]([N:29]4[CH:30]=[CH:31][N:32]=[C:28]4[C:25]4[CH:24]=[CH:23][C:22]([F:21])=[CH:27][N:26]=4)[N:11]=[CH:10][C:9]=3[N:8]([CH3:12])[C:7](=[O:13])[C@H:6]2[CH2:14][CH3:15])[CH2:20][CH2:19][CH2:18][CH2:17]1Komponenten
3
Versuchsvorschrift
The title compound was prepared similarly to the methods described in Example 77, with Intermediate B instead of Intermediate C and with 5-fluoro-2-(1H-imidazol-2-yl)pyridine instead of 2-phenyl-1H-imidazole. LCMS: 422.3 m/z (M+H)+; ret. Time: 6.73 min (Analytical Method C).
Quellen und Nachweise
- ORD-Eintrag