5-Bromo-2-(trifluoromethyl)isonicotinonitrile → 4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid methyl ester

HRID 448936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 448936
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8](B2OC(C)(C)C(C)(C)O2)[C:7]([Cl:19])=[CH:6][C:5]=1[O:20][CH3:21].Br[C:24]1[C:29]([C:30]#[N:31])=[CH:28][C:27]([C:32]([F:35])([F:34])[F:33])=[N:26][CH:25]=1>>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([C:24]2[CH:25]=[N:26][C:27]([C:32]([F:34])([F:35])[F:33])=[CH:28][C:29]=2[C:30]#[N:31])[C:7]([Cl:19])=[CH:6][C:5]=1[O:20][CH3:21]

Komponenten

3

Edukt 2

HCID 569733155-Bromo-2-(trifluoromethyl)isonicotinonitrileHCID 57362634Methyl 4-chloro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Produkt 1

HCID 686025434-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid methyl esterAusbeute 49,4 %

Versuchsvorschrift

4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid methyl ester (5.5 g) was prepared according to Step 2E.1 from 4-chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester (9.8 g) and 5-bromo-2-trifluoromethyl-isonicotinonitrile 1-1 (7.6 g). MS [M+H]+: 371.0; tR=2.83 min (method 1)

Quellen und Nachweise

ORD-Eintrag
ord-49007829d96f4145aa8a46f97102a213
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481738B2

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