4-Bromophenol → 2-(4-Bromophenoxy)-1-fluoro-3-methoxybenzene

Beteiligte Stoffe

Reaktionsschritte

Into a 100 mL round bottom flask was added 4-bromophenol (2.04 g, 11.8 mmol), 6-fluoro-2-methoxyphenylboronic acid (1.00 g, 5.88 mmol), cupric acetate (1.4 g, 7.70 mmol) and DCM (50 mL). TEA (4.0 mL, 29.0 mmol) was then added followed by 4 A° molecular sieves and the reaction mixture was stirred at rt for 48 h. Reaction mixture was then filtered through celite. The filtrate was concentrated in vacuo to give a residue which was purified by silica gel chromatography, eluting with 5% EtOAc in hexane.

Herkunft & Nachweise