Dichloromethane → 1-Chloro-2-nitro-4-phenoxybenzene

HRID 449117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 449117
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12]1(B(O)O)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(Cl)Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 66827Phenylboronic AcidHCID 691274-Chloro-3-nitrophenol

Produkt 1

HCID 219378011-Chloro-2-nitro-4-phenoxybenzene

Versuchsvorschrift

4-Chloro-3-nitrophenol (2.0 g, 0.012 mol), phenylboronic acid (3.5 g, 0.029 mol), TEA (9.6 mL, 0.069 mol), cupric acetate (3.3 g, 0.018 mol) and DCM (100 mL, 2 mol) were added to a 100 mL oven dried flask and the reaction was stirred at rt for 48 h. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in Hexane).

Aufarbeitung

  1. customdried flask
  2. customThe solvent was then removed under reduced pressure
  3. customthe resulting residue was purified by flash chromatography (5% EtOAc in Hexane)

Quellen und Nachweise

ORD-Eintrag
ord-7cf3189f15d844afaa2201c587b71062
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481733B2

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