Dimethylamine → HCID 67128887, Verbindung

HRID 449923

Reaktionsgleichung

Reaktionsgleichung von HRID 449923
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](O)=[O:12])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5].C1N=[CH:18][N:17](C(N2C=NC=C2)=O)[CH:16]=1.CNC>ClC1CC(C(C)C)CCC1(Cl)C>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:12])[N:17]([CH3:18])[CH3:16])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 39047Benzenedicarboxylic acid, dichloro-HCID 682631,1'-Carbonyldiimidazole

Produkt 1

HCID 67128887HCID 67128887, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21946423DichloromenthaneLösungsmittel

Versuchsvorschrift

To a solution of 2,6-dichloroterephthalic acid (100 mg, 0.46 mmol) in dichloromenthane was added CDI (62 mg, 0.46 mmol) in one portion. The reaction mixture was stirred at room temperature for 1.5 hours and then dimethyl amine (1.0 M in THF, 2 mL, 2.0 mmol) was added. The reaction was concentrated under reduced pressure to give the crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid, which was used in the next step without further purification. 1H NMR (500 MHz, DMSO-d6): δ 14.35 (s, 1H), 7.56 (s, 2H), 2.97 (s, 3H), 2.89 (s, 3H).

Aufarbeitung

  1. concentrationThe reaction was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-763c3c867a3e45b58807a5388d5794a5
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486950B2

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