Thionyl Chloride → 2,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chloride

HRID 449924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 449924
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4](O)=[O:5].O=S(Cl)[Cl:19]>>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4]([Cl:19])=[O:5]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 671288872,6-Dichloro-4-(dimethylcarbamoyl)benzoic acid

Produkt 1

HCID 866489622,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chlorideAusbeute 100 %

Versuchsvorschrift

A solution of 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid (65 mg, 0.21 mmol) in SOCl2 (3 mL) was heated to reflux for overnight and then cooled to room temperature. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoyl chloride (70 mg, yield: 100%), which was used in the next step without further purification.

Aufarbeitung

  1. temperatureto reflux for overnight
  2. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4d307f5cca2e408dab15fb76c86b15f4
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486950B2

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