Sodium Hydroxide → HCID 66801910, Verbindung

HRID 449926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 449926
[Cl:1][C:2]1[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[CH:9]=[C:8]([F:16])[C:3]=1[C:4]([O:6][CH3:7])=[O:5].[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:11]=[C:10]([CH:9]=[C:8]([F:16])[C:3]=1[C:4]([O:6][CH3:7])=[O:5])[C:12]([OH:14])=[O:13]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66801766HCID 66801766, Verbindung

Produkt 1

HCID 66801910HCID 66801910, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of dimethyl 2-chloro-6-fluoroterephthalate (2.784 g, 11.3 mmoles) in tetrahydrofuran (20 mL) was added a solution of 1 N NaOH (12.4 mmol, 12.4 mL). The reaction mixture was stirred at room temperature for 30 min. The reaction was concentrated under reduced pressure and the residue was suspended in water (10 mL). The aqueous solution was acidified to pH 3 with 1 N HCl. The resulting white precipitate was collected by filtration, washed with water and ether, dried in high vacuum to afford 3-chloro-5-fluoro-4-(methoxycarbonyl)benzoic acid as a white solid (2.52 g, yield: 96%). 1H NMR (400 MHz, CDCl3) δ 7.96 (s, 1H), 7.76 (dd, J=8.8, 1.3 Hz, 1H), 4.01 (s, 3H). LCMS (APCI+) [M+H]+233.0.

Aufarbeitung

  1. concentrationThe reaction was concentrated under reduced pressure
  2. filtrationThe resulting white precipitate was collected by filtration
  3. washwashed with water and ether
  4. customdried in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-588e676ff8d74d5e9bae935201a49f17
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486950B2

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