Ammonia → 4-Aminobenzamide

HRID 450033

Reaktionsgleichung

Reaktionsgleichung von HRID 450033
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH3:11]>O1CCCC1>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:11])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 177720Benzoyl chloride, 4-amino-

Produkt 1

HCID 760794-AminobenzamideAusbeute 30 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 4-amino-benzoyl chloride (0.38 g, 2.45 mmol) in tetrahydrofuran (2 ml) was added aqueous ammonia solution (15 ml). The reaction mixture was stirred at room temperature for 12 hr. The solvent was removed under vacuum, water added and the compound was extracted into ethyl acetate. The organic layer was dried and concentrated under vacuum. The crude compound was purified using silica gel column chromatography, using chloroform/methanol as eluent, to yield 4-amino-benzamide (0.1 g, 30%).

Aufarbeitung

  1. customThe solvent was removed under vacuum, water
  2. additionadded
  3. extractionthe compound was extracted into ethyl acetate
  4. customThe organic layer was dried
  5. concentrationconcentrated under vacuum
  6. customThe crude compound was purified

Quellen und Nachweise

ORD-Eintrag
ord-77b9532ce9694d63ae78c3ee0bbc54e6
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

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