Dimethylamine → N,N-Dimethyl-4-nitrobenzylamine

HRID 450067Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450067
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH3:18][NH:19][CH3:20]>C(#N)C>[CH3:18][N:19]([CH3:20])[CH2:8][C:7]1[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 660114-Nitrobenzyl bromide

Produkt 1

HCID 278498N,N-Dimethyl-4-nitrobenzylamineAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of 4-nitrobenzyl bromide (4 g, 18.5 mmol) and potassium carbonate (7.65 g, 55.5 mmol) in acetonitrile (50 ml) at 0-5° C. was added 40% aqueous dimethyl amine solution (1.5 eq). After 1 hr at room temperature, the solvent was evaporated; the crude material was dissolved in water and extracted with ethyl acetate. The organic layer was dried and concentrated to give dimethyl-(4-nitro-benzyl)-amine (2.8 g, 84%)

Aufarbeitung

  1. customthe solvent was evaporated
  2. dissolutionthe crude material was dissolved in water
  3. extractionextracted with ethyl acetate
  4. customThe organic layer was dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bd2fb2eba8554bfdb8b410859dc681eb
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

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