(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 450077

Reaktionsgleichung

Reaktionsgleichung von HRID 450077
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 24386Thionyl Chloride

Produkt 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-Ausbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To mixture of p-nitrophenylacetic acid (1 g, 5.5 mmol) in benzene (10 ml) was added thionyl chloride (0.8 ml) at room temperature. The reaction mixture was heated to reflux for 12 hr and then cooled. The excess thionyl chloride and benzene were removed in vacuo to obtain (4-nitro-phenyl)-acetyl chloride (1 g, 91%).

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 12 hr
  3. temperaturecooled
  4. customThe excess thionyl chloride and benzene were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f9c31a1a115c401fa9f3dac308421650
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

Verknüpfte Notizen

Wird geladen…