4-Nitrophenol → 1-Nitro-4-(2,2,3,3-tetrafluoropropoxy)benzene

Temperatur

105 °C

To a solution of 4-nitro phenol (860 mg, 6.1 mmol) in DMF (10 ml) was added potassium carbonate (1.4 g, 10 mmol) and 1,1,2,2-tetrafluoro-3-iodo-propane (500 mg, 2 mmol). The reaction mixture was heated at 100-110° C. for 6 hr, then cooled to room temperature and filtered. The filtrate was diluted with ethyl acetate (100 ml), then washed once with 5% sodium hydroxide solution, several times with water, and finally brine. The organic layer was then dried over anhydrous sodium sulfate, filtered, and evaporated to dryness to give 1-nitro-4-(2,2,3,3-tetrafluoro-propoxy)-benzene (360 mg, 68%) as solid.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. additionThe filtrate was diluted with ethyl acetate (100 ml)
4. washwashed once with 5% sodium hydroxide solution, several times with water, and finally brine
5. dry with materialThe organic layer was then dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customevaporated to dryness

ORD-Eintrag

ord-b9e4c414742c491f86044bfc0296ec7a

Quelldatensatz

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08486962B2