Sodium Hydroxide → HCID 46182215, Verbindung
Reaktionsgleichung
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[N:14]=[C:13]([O:15][CH:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[C:12]([NH:22][C:23]2[C:24]3[C:31]([CH3:32])=[C:30]([C:33]([O:35]C)=[O:34])[S:29][C:25]=3[N:26]=[CH:27][N:28]=2)=[CH:11][CH:10]=1.OS([O-])(=O)=O.[K+]>>[CH3:3][O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[N:14]=[C:13]([O:15][CH:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)[C:12]([NH:22][C:23]2[C:24]3[C:31]([CH3:32])=[C:30]([C:33]([OH:35])=[O:34])[S:29][C:25]=3[N:26]=[CH:27][N:28]=2)=[CH:11][CH:10]=1Komponenten
4
Versuchsvorschrift
Aqueous NaOH (2M, 0.175 mL) was added into a suspension of methyl 4-(6-(3-methoxypropoxy)-2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (0.034 g, 0.07 mmol) and the reaction mixture stirred at ambient temperature for 18 hours. The solution was adjusted to pH 2 using 10% aqueous KHSO4 and the resultant suspension was filtered. The solid was washed with water, diethyl ether and dried in vacuo over P2O5 to afford off-white solid (0.024 g, 73%).