Ammonia → 3-(5-(6-Chloropyridin-3-yl)-1,2,4-oxadiazol-3-yl)benzonitrile
Reaktionsgleichung
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](=[N:8][OH:9])[NH2:7])#[N:2].[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=O)=[CH:16][N:15]=1.N>>[Cl:13][C:14]1[N:15]=[CH:16][C:17]([C:18]2[O:9][N:8]=[C:6]([C:5]3[CH:4]=[C:3]([CH:12]=[CH:11][CH:10]=3)[C:1]#[N:2])[N:7]=2)=[CH:21][CH:22]=1Komponenten
4
Versuchsvorschrift
The title compound was prepared according to the procedure of Example 4B using 3-cyano-N′-hydroxybenzimidamide (Example 4A) and 6-chloronicotinoyl chloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.87 (m, 2 H), 8.17 (m, 1 H), 8.4 (m, 1 H), 8.43 (d, J=1.7 Hz, 1 H), 8.6 (m, 1 H), 9.25 (d, J=1.7 Hz, 1 H) ppm; MS (DCI/NH3) m/z 283 (M+H)+.