3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamine → HCID 178418500, Verbindung

HRID 4510

Reaktionsgleichung

Reaktionsgleichung von HRID 4510
[N:1]1[C:10]2[CH:9]([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[N+](N[C:19]1[NH:20][CH:21]=[C:22]([CH2:26][C:27]2[CH:28]=[N:29][C:30]([CH3:33])=[CH:31][CH:32]=2)[C:23](=[O:25])[N:24]=1)([O-])=O>N1C=CC=CC=1>[N:1]1[C:10]2[CH:9]([CH2:11][CH2:12][CH2:13][NH:14][C:19]3[NH:20][CH:21]=[C:22]([CH2:26][C:27]4[CH:28]=[N:29][C:30]([CH3:33])=[CH:31][CH:32]=4)[C:23](=[O:25])[N:24]=3)[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 198517793-(5,6,7,8-Tetrahydroquinol-8-yl)propylamineHCID 178418530HCID 178418530, Verbindung

Produkt 1

HCID 178418500HCID 178418500, VerbindungAusbeute 26,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 3-(5,6,7,8-tetrahydroquinol-8-yl)-propylamine (0.75 g, 0.0038 mole) and 2-nitroamino-5-(6-methylpyrid-3-ylmethyl)-4(1H)-pyrimidone (0.99 g, 0.0037 mole) in pyridine (1 ml) was refluxed for 8 hr and evaporated to dryness. The residue was chromatographed on silica in 10% MeOH/CHCl3 then dissolved in hot CHCl3, filtered, and the product precipitated with petroleum ether 40°-60° C. to give the title compound (0.38 g), m.p. 75°-80° C.

Aufarbeitung

  1. customevaporated to dryness
  2. customThe residue was chromatographed on silica in 10% MeOH/CHCl3
  3. dissolutionthen dissolved in hot CHCl3
  4. filtrationfiltered
  5. customthe product precipitated with petroleum ether 40°-60° C.

Quellen und Nachweise

ORD-Eintrag
ord-9fa178249b754b389254ccf16bc7859d
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727076

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