Ethyl isothiocyanatoformate → Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate

HRID 451458

Reaktionsgleichung

Reaktionsgleichung von HRID 451458
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[CH2:9]([O:11][C:12]([N:14]=[C:15]=[S:16])=[O:13])[CH3:10]>O1CCOCC1>[Br:1][C:2]1[C:3]([NH:8][C:15]([NH:14][C:12]([O:11][CH2:9][CH3:10])=[O:13])=[S:16])=[N:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 85320Ethyl isothiocyanatoformate2×HCID 8177002-Amino-3-bromopyridine

Produkt 1

HCID 59199107Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3-Bromopyridin-2-amine (30 g, 168 mmol) and ethoxycarbonyl isothiocyanate (24.8 g, 21.3 mL, 185 mmol) were dissolved in dioxane (300 mL) and stirred at room temperature. After 4 hours further ethoxycarbonyl isothiocyanate (1 mL, 8.4 mmol) was added. After 1 hour the solvent was evaporated and the residue dried in high vacuum for 12 hours. The title compound was obtained as a light yellow solid (51.2 g, 100%) and was used crude for the next step.

Aufarbeitung

  1. customAfter 1 hour the solvent was evaporated
  2. customthe residue dried in high vacuum for 12 hours

Quellen und Nachweise

ORD-Eintrag
ord-a9bcd574b9cf4198bd995cafa9a169f3
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486967B2

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