L-Methionine → 3-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazole

HRID 45152

Reaktionsgleichung

Reaktionsgleichung von HRID 45152
[CH3:1][C:2]1[N:3]([C:8]2[CH:12]=[C:11]([CH:13]([CH3:15])[CH3:14])[NH:10][N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[H-].[Na+].N[C@H:19](C(O)=O)CCSC.[Cl-].[NH4+]>C1COCC1.C(Cl)Cl>[CH3:1][C:2]1[N:3]([C:8]2[N:9]([CH3:19])[N:10]=[C:11]([CH:13]([CH3:15])[CH3:14])[CH:12]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH3:1][C:2]1[N:3]([C:8]2[CH:12]=[C:11]([CH:13]([CH3:15])[CH3:14])[N:10]([CH3:19])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1

Komponenten

8

Edukt 4

HCID 6137L-MethionineHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 593940413-(2,5-dimethyl-pyrrol-1-yl)-5-isopropyl-1H-pyrazole

Produkt 2

HCID 674314505-(2,5-Dimethyl-pyrrol-1-yl)-3-isopropyl-1-methyl-1H-pyrazoleAusbeute 29 %HCID 674331323-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazoleAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-(2,5-dimethyl-pyrrol-1-yl)-5-isopropyl-1H-pyrazole (7.7 g, 37.9 mmol) in THF (400 mL) that is purged with nitrogen is added NaH (2.272 g, 56.8 mmol) at 0° C. The mixture is stirred for 10 min in the ice bath then for 10 min at room temperature. Met (4.74 mL, 76 mmol) is added and the mixture is stirred at room temperature for 1 h. At that point the reaction is diluted with DCM and treated with saturated solution of ammonium chloride (10 mL). The mixture is concentrated to dryness and the residue is partitioned in water and DCM. The organic layer is combined, dried over sodium sulfate, concentrated and absorbed onto silica to purify by FCC (0-30% EtOAC/Heptane) to give 5-(2,5-Dimethyl-pyrrol-1-yl)-3-isopropyl-1-methyl-1H-pyrazole (2.4 g, 29%) as the first peak and 3-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazole (5.24 g, 63%) as the second peak. MS (ESI) m/z 218.3 (m+1).

Aufarbeitung

  1. concentrationThe mixture is concentrated to dryness
  2. customthe residue is partitioned in water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customabsorbed onto silica
  6. customto purify by FCC (0-30% EtOAC/Heptane)

Quellen und Nachweise

ORD-Eintrag
ord-d0b6d568edcc42c4baf54071ba01d9ce
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541432B2

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