Hydrochloric Acid → HCID 86596673, Verbindung

HRID 451617

Reaktionsgleichung

Reaktionsgleichung von HRID 451617
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[N:15](OCCC(C)C)=[O:16].Cl>CO>[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[C:9](=[N:15][OH:16])[CH2:8]2)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

Produkt 1

HCID 86596673HCID 86596673, VerbindungAusbeute 137,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-tert-butyl-indan-1-one (9.39 g, 39 mmol) was dissolved in 150 ml methanol. Isoamyl nitrite (5 g, 43 mmol) and conc. HCl (5 ml) were added, and the reaction stirred at ambient temperature for 44 hours. The solvents were removed under vacuum to give 11.67 grams of crude product which was used without further purification. 1H NMR (300 MHz, CDCl3) 7.82 (d, 1H), 7.51 (s, 1H), 7.49 (d, 1H), 3.83 (s, 2H), 3.50 (s, 1H, OH) 1.34 (s, 9H). MS (CSI) m/e 218 (M+H)+, 235 (m+NH4)+

Aufarbeitung

  1. customThe solvents were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-33f1e9d4c2fa409d9d3d76d67b539f6d
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08487116B2

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