8-Chloro-2-(2-(diethylamino)ethyl)-2H-(1)benzothiopyrano(4,3,2-cd)indazole-5-methanol → (E)-7-(3-pyridyl)-7-phenyl-6-heptenoic acid hydrochloride
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[C:7](/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8]/[CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:2]=1.CCN(CCN1N=C2C3C(SC4C=C([Cl:47])C=CC=42)=C(CO)C=CC1=3)CC>Cl>[ClH:47].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[C:7](/[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:8]/[CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:2]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To (E)-7-(3-pyridyl)-7-phenyl-6-heptenoic acid (Ia-4, 300 mg was dissolved in 2N HCl (5 ml). The solution was concentrated under reduced pressure. Recrystallization of the resulting crystals from ethanol-isopropyl ether gave (E)-7-(3-pyridyl)-7-phenyl-6-heptenoic acid hydrochloride (Ii-75) (285 mg), m.p. 163°-165° C. Physicochemical properties including other data are shown in Table 6.