Hydrochloric Acid → Metformin Hydrochloride

Beteiligte Stoffe

Reaktionsschritte

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

Herkunft & Nachweise