Ethyl 4-phenyl-1,3-thiazole-2-carboxylate → 4-Phenylthiazole-2-carboxylic acid

HRID 453299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 453299
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:10]=1)=[O:5])C>C1COCC1.[OH-].[Na+]>[C:11]1([C:9]2[N:10]=[C:6]([C:4]([OH:5])=[O:3])[S:7][CH:8]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 24730326Ethyl 4-phenyl-1,3-thiazole-2-carboxylate

Produkt 1

HCID 38785394-Phenylthiazole-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Ethyl-4-phenylthiazole-2-carboxylate (300 mg) was stirred overnight in a mixture of THF (4 mL) and 1N aqueous NaOH (1 mL) for 18 hours. The THF was removed under reduced pressure and the aqueous solution was acidified with 4N HCl, extracted with CH2Cl2, dried over Na2SO4 and concentrate to obtain 4-phenylthiazole-2-carboxylic acid which was used as is in the next step.

Aufarbeitung

  1. customThe THF was removed under reduced pressure
  2. extractionextracted with CH2Cl2
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrate

Quellen und Nachweise

ORD-Eintrag
ord-ebe37f5047ed465890e100c15a560b13
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492401B2

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