2-Hydroxy-3,4,6-trimethylbenzaldehyde → 2,3,5,6-Tetramethylphenol

HRID 453419

Reaktionsgleichung

Reaktionsgleichung von HRID 453419
[OH:1][C:2]1[C:9]([CH3:10])=[C:8]([CH3:11])[CH:7]=[C:6]([CH3:12])[C:3]=1[CH:4]=O>CO.[C].[Pd]>[CH3:4][C:3]1[C:6]([CH3:12])=[CH:7][C:8]([CH3:11])=[C:9]([CH3:10])[C:2]=1[OH:1]

Komponenten

4

Edukt 1

HCID 113211462-Hydroxy-3,4,6-trimethylbenzaldehyde

Produkt 1

HCID 106942,3,5,6-TetramethylphenolAusbeute 12,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Hydroxy-3,4,6-trimethylbenzaldehyde (6.58 g, 40.1 mmol) was dissolved in methanol (120 mL), 10% palladium-carbon (50% water-containing product, 1.0 g) was added under hydrogen atmosphere (balloon pressure), and the mixture was stirred at room temperature for 22 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The precipitated crystals were recrystallized from methanol to give the title compound (0.73 g, yield 12%) as colorless crystals. The mother solution was concentrated under reduced pressure to give second crop (5.10 g, yield 85%).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe precipitated crystals were recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-dc76604064ae4a79a08bba08857ce0dc
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492430B2

Verknüpfte Notizen

Wird geladen…