Trifluoroacetic acid → 2-(6-(10-Chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetic acid

HRID 453873Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 453873
[Cl:1][C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]2[CH2:11][CH2:12][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH:20]=[CH:21][N:22]4[CH2:25][C:26]([O:28]C(C)(C)C)=[O:27])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]2[CH2:11][CH2:12][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH:20]=[CH:21][N:22]4[CH2:25][C:26]([OH:28])=[O:27])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59473664tert-Butyl 2-(6-(10-chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetate

Produkt 1

HCID 594736922-(6-(10-Chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetic acidAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

tert-Butyl 2-(6-(10-chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetate (2.22 mmol, 1.0 equiv.) was dissolved in DCM (15 ml); TFA (3 ml) was added, and the mixture was stirred for 2 h at 25° C. The solvent was concentrated under reduced pressure, and the residue was taken up in DCM (60 ml), washed with water (25 ml) and sat. NaCl solution (25 ml), dried over Na2SO4 and concentrated to dryness under reduced pressure. Yield: 91%

Aufarbeitung

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washwashed with water (25 ml) and sat. NaCl solution (25 ml)
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-83328893d0c841d88cfda820013150b0
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492559B2

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