4-Fluorobenzyl chloride → 5-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

HRID 453940

Reaktionsgleichung

Reaktionsgleichung von HRID 453940
[CH3:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-:10])=[O:9].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:12][C:4]2[CH:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)=[CH:16][CH:15]=1

Komponenten

5

Edukt 3

HCID 96024-Fluorobenzyl chlorideHCID 11430Potassium CarbonateHCID 1384663,5-Dimethyl-4-nitrophenol

Produkt 1

HCID 670834645-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 3,5-dimethyl-4-nitrophenol (0.97 g, 5.79 mmol), 4-fluorobenzyl chloride (1.26 g, 8.69 mmol) and anhydrous potassium carbonate (1.24 g, 9.0 mmol) in 50 ml of acetone was stirred under reflux for 22 hours. TLC showed this reaction is complete. The reaction mixture was cooled to room temperature and filtered and washed with acetone. The filtrate was evaporated to dryness to give the crude product, which was used for next step without further purification.

Aufarbeitung

  1. temperatureunder reflux for 22 hours
  2. filtrationfiltered
  3. washwashed with acetone
  4. customThe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a6ac003ef0014afa89d6ce38f6a7d273
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492588B2

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