Ammonia → 7-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one

HRID 454229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454229
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][O:10][C:11]2[CH:20]=[C:19]3[C:14]([C:15](=[O:29])[N:16](COC(=O)C(C)(C)C)[CH:17]=[N:18]3)=[CH:13][C:12]=2[O:30][CH3:31])[CH2:4][CH2:3]1.N>CO>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][O:10][C:11]2[CH:20]=[C:19]3[C:14]([C:15](=[O:29])[NH:16][CH:17]=[N:18]3)=[CH:13][C:12]=2[O:30][CH3:31])[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 111128387-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

Produkt 1

HCID 1354507917-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-oneAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 7-(2-(1-methylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (4.2 g, 9.7 mmol) in methanol saturated with ammonia (150 ml) was stirred overnight at ambient temperature. The volatiles were removed under vacuum and the residue was triturated with ether. The solid was filtered, washed with ether and dried under vacuum to give 7-(2-(1-methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (3.12 g, 100%).

Aufarbeitung

  1. customThe volatiles were removed under vacuum
  2. customthe residue was triturated with ether
  3. filtrationThe solid was filtered
  4. washwashed with ether
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-62367d55a4c8443d9dd6f4fb3ad701cb
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492560B2

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