Ammonia → 6-Methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-3,4-dihydroquinazolin-4-one

HRID 454238Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454238
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:21]=[C:20]3[C:15]([C:16](=[O:30])[N:17](COC(=O)C(C)(C)C)[CH:18]=[N:19]3)=[CH:14][C:13]=2[O:31][CH3:32])[CH2:4][CH2:3]1.N>CO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:21]=[C:20]3[C:15]([C:16](=[O:30])[NH:17][CH:18]=[N:19]3)=[CH:14][C:13]=2[O:31][CH3:32])[CH2:6][CH2:7]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 220306066-Methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

Produkt 1

HCID 1354581696-Methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-3,4-dihydroquinazolin-4-oneAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 7-(3-(4-methylpiperazin-1-yl)propoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (31.8 g, 71.3 mmol) in methanol saturated with ammonia was stirred at ambient temperature overnight. The volatiles were removed under vacuum. The solid was triturated with ether containing about 10% of methylene chloride, filtered, washed with ether containing about 10% methylene chloride and dried under vacuum to give 7-(3-(4-methylpiperazin-1-yl)propoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (22.63 g, 95%).

Aufarbeitung

  1. customThe volatiles were removed under vacuum
  2. customThe solid was triturated with ether containing about 10% of methylene chloride
  3. filtrationfiltered
  4. washwashed with ether containing about 10% methylene chloride
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fbdd7638d0f6465d8bbe59ea90241b24
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492560B2

Notizen zur Reaktion

Wird geladen…