Sodium Hydroxide → 2-(Benzyloxy)-5-(oxazol-5-yl)benzoic acid

HRID 454481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454481
[OH-].[Na+].[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][CH:24]=[N:23][CH:22]=2)=[CH:17][C:12]=1[C:13]([O:15]C)=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O1CCOCC1>[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][CH:24]=[N:23][CH:22]=2)=[CH:17][C:12]=1[C:13]([OH:15])=[O:14])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66990185Methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate

Produkt 1

HCID 669904842-(Benzyloxy)-5-(oxazol-5-yl)benzoic acidAusbeute 87,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A 2 mol/L aqueous solution of sodium hydroxide (4.5 mL) was added to a dioxane (5 mL) solution of the obtained methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate (0.55 g), followed by stirring at room temperature for 2 hours and 40 minutes. The solvent was evaporated under reduced pressure, and water was added to the residue. After adjusting the pH to 4.0 with 6 mol/L hydrochloric acid, the solid substance was collected by filtration to obtain 0.46 g of 2-(benzyloxy)-5-(oxazol-5-yl)benzoic acid as a light yellow solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure, and water
  2. additionwas added to the residue
  3. filtrationthe solid substance was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-56ae76fa954e4a91af3af4c37ee4fd94
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492582B2

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