Trifluoroacetic acid → 2-(2-Hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

HRID 454581Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454581
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>C(Cl)Cl>[OH:8][C:9]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 58508748Tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate

Produkt 1

HCID 468536212-(2-Hydroxy-5-phenylbenzamido)-4-phenylbenzoic acidAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (1 mL) was added to a methylene chloride (3 mL) solution of the obtained tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate (0.085 g), followed by stirring at room temperature for 17 hours. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the residue. The solid substance was collected by filtration to obtain 0.072 g of 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid as a white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure, and ethyl acetate
  2. additionwas added to the residue
  3. filtrationThe solid substance was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5ea47a02dab145319251d3c9841217d9
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492582B2

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