Trifluoroacetic acid → 4-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

HRID 454732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454732
FC(F)(F)C(O)=O.[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([O:20]C(C)(C)C)=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([OH:20])=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 58508784Tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate

Produkt 1

HCID 585086024-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

Versuchsvorschrift

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and methanol was added to the obtained residue. The solid substance was collected by filtration to obtain 53 mg of 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure, and methanol
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7de150240329499c82a64376f700eb42
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492582B2

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