Trifluoroacetic acid → HCID 58508471, Verbindung

HRID 454772Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454772
FC(F)(F)C(O)=O.C(OC([O:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[C:24]([NH:35][C:36]([C:38]3[CH:39]=[N:40][CH:41]=[C:42]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[CH:43]=3)=[O:37])[CH:23]=2)[CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C>>[OH:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([OH:28])=[O:27])=[C:24]([NH:35][C:36]([C:38]3[CH:39]=[N:40][CH:41]=[C:42]([C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=4)[CH:43]=3)=[O:37])[CH:23]=2)[CH:19]=[CH:20][CH:21]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 66990697HCID 66990697, Verbindung

Produkt 1

HCID 58508471HCID 58508471, Verbindung

Versuchsvorschrift

Trifluoroacetic acid (4.0 mL) was added to the obtained tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 1 hour and 15 minutes. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 70 mg of 4-(3-hydroxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-080ecd2a5055458aa60e11edab428afc
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492582B2

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