Sodium hydride → 2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium hydride	HCID 24758	—
Edukt	3-Fluoro-1-propanol	HCID 68042	—
Edukt	2-(2-Chloropyrimidine-4-yl)-6-methoxybenzothiophene	HCID 86646555	—
Produkt	2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene	HCID 46947547	65,4%

Reaktionsschritte

2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene (1-32, 75 mg, 65%) was prepared in the same manner as in Example 31 as a pale yellow solid using 3-fluoro-1-propanol (40 mL, 0.54 mmol), sodium hydride (NaH, 22 mg, 0.54 mmol) and 2-(2-chloropyrimidine-4-yl)-6-methoxybenzothiophene (105a, 100 mg, 0.36 mmol) obtained in Preparation Example 19.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08497260B2
Quelldatensatz	uspto-grants-2013_07
ORD ID	ord-7174684f3c7f4527b7c6cfe771d1f13c
Quellennotiz	uspto-grants-2013_07