4,5-Dimethylthiazole-2(3H)-thione → 4,5-Dimethyl-3-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-3H-thiazole-2-thione
Reaktionsgleichung
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1.[CH3:21][C:22]1[NH:23][C:24](=[S:28])[S:25][C:26]=1[CH3:27]>>[CH3:21][C:22]1[N:23]([CH2:3][C:4]2[N:8]3[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:7]3=[N:6][C:5]=2[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[C:24](=[S:28])[S:25][C:26]=1[CH3:27]Komponenten
3
Versuchsvorschrift
The title compound was prepared according to Method A and the experimentals described for compound 92 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 4,5-dimethylthiazole-2(3H)-thione. m/e+ 380 for C21H22N3S2 [M+H]+; 1H-NMR (400 MHz, CDCl3) δ 7.96 (s, 1H), 7.65 (d, J=8.0 Hz, 2H), 7.55 (d, J=8.8 Hz, 1H), 7.26 (d, J=8.0 Hz, 2H), 7.08 (dd, J=1.4, 9.1 Hz, 1H), 4.83 (s, 2H), 2.39 (s, 3H), 2.35 (s, 3H), 2.29 (s, 3H), 2.28 (s, 3H) ppm; 13C-NMR (100 MHz, CDCl3, δ) 156.250, 149.085, 145.149, 144.391, 137.642, 131.159, 129.347, 128.748, 128.217, 127.929, 122.090, 121.794, 116.828, 113.612, 30.301, 21.308, 18.449, 14.688, 11.374 ppm.
Quellen und Nachweise
- ORD-Eintrag
- ord-2f05bd2122d74b5e98500c731ae78408
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08497278B2
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