4-Hydroxypyrrolidine → HCID 67027734, Verbindung

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Hydroxypyrrolidine	HCID 98210	—
Edukt	(R)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amine	HCID 58337026	—
Edukt	2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine	HCID 86655124	—
Produkt	HCID 67027734	HCID 67027734	—

Reaktionsschritte

The title compound was prepared according to the experimental for compound 183 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and pyrrolidin-3-ol. M/e+ 406 for C22H21ClN5O (M+H)−; 1H-NMR (400 MHz, CDCl3) δ 8.20 (d, J=6.9 Hz, 1H), 7.91 (dd, J=6.6, 1.8 Hz, 2H), 7.75 (d, J=8.4 Hz, 2H), 7.62 (d, J=9.1 Hz, 1H), 7.42 (d, J=8.4 Hz, 2H), 7.20 (m, 1H), 6.79 (td, J=6.9, 1.1 Hz, 1H), 4.59 (s, 1H), 4.35 (s, 2H), 3.54 (m, 3H), 2.09 (m, 2H), 1.55 (s, 1H) ppm

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08497278B2
Quelldatensatz	uspto-grants-2013_07
ORD ID	ord-c0f9f29fcfc340fd9ea7eb6b8d918f96
Quellennotiz	uspto-grants-2013_07