Ammonia → 2-Amino-1-(4-chlorophenyl)-1-(4-iodophenyl)ethanol

HRID 455325

Reaktionsgleichung

Reaktionsgleichung von HRID 455325
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=3)[CH2:10][O:9]2)=[CH:4][CH:3]=1.CO.[NH3:20]>>[NH2:20][CH2:10][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([C:11]1[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=1)[OH:9]

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 887MethanolHCID 593172172-(4-Chlorophenyl)-2-(4-iodophenyl)oxirane

Produkt 1

HCID 250132692-Amino-1-(4-chlorophenyl)-1-(4-iodophenyl)ethanol

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

2-(4-Chloro-phenyl)-2-(4-iodo-phenyl)-oxirane (500 mg, 1.40 mmol) was dissolved in 2M NH3 in methanol (5 ml, 10.0 mmol) and the solution was heated in a microwave at 130° C. for 60 minutes. Upon cooling, the solvent was removed in vacuo to furnish the desired product. Three identical reactions were carried out and afforded 1.55 g (98%) of the product 2-amino-1-(4-chloro-phenyl)-1-[4-iodo-phenyl]-ethanol. The crude product was pure and was used in the next step without purification.

Aufarbeitung

  1. temperatureUpon cooling
  2. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d87d8571873a4d2d9b7ef0414d3f972e
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08497294B2

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