HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,3-Dibromopropane → Didesmethylsibutramine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,3-Dibromopropane | HCID 8001 | — |
| Edukt | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| Produkt | Didesmethylsibutramine | HCID 134772 | 56,2% |
Reaktionsschritte
As described in article (Chinese Journal of Pharmaceuticals, 2001, 32(8): 337-339), p-chlorobenzyl cyanide was condensed with 1,3-dibromopropane, cycled to give cyclobutyl intermediate, and then through Grignard reaction and reduction reaction to give title compound (56.2% yield).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08497305B2 |
| Quelldatensatz | uspto-grants-2013_07 |
| ORD ID | ord-f61af2fe89974ddbb36cdcc704faf1e5 |
| Quellennotiz | uspto-grants-2013_07 |