1-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone → 1-(1-(1-(7-Fluoroquinolin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone

HRID 456144

Reaktionsgleichung

Reaktionsgleichung von HRID 456144
N1C2C(=CC(CN3C4=NC(C(=O)C)=CN=C4N=N3)=CC=2)C=CC=1.C([O:26][C:27]([C:29]1[N:34]=[C:33]2[N:35]([CH:38]([C:40]3[CH:41]=[C:42]4[C:47](=[CH:48][C:49]=3[F:50])[N:46]=[CH:45][CH:44]=[CH:43]4)[CH3:39])[N:36]=[N:37][C:32]2=[N:31][CH:30]=1)=[CH2:28])C>>[F:50][C:49]1[CH:48]=[C:47]2[C:42]([CH:43]=[CH:44][CH:45]=[N:46]2)=[CH:41][C:40]=1[CH:38]([N:35]1[C:33]2=[N:34][C:29]([C:27](=[O:26])[CH3:28])=[CH:30][N:31]=[C:32]2[N:37]=[N:36]1)[CH3:39]

Komponenten

3

Edukt 2

HCID 593418021-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanoneHCID 669272076-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

Produkt 1

HCID 669271571-(1-(1-(7-Fluoroquinolin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone

Versuchsvorschrift

The title compound was prepared in analogy to the synthesis of compound of 52.4 from 6-(1-(6-(1-ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.44 (s, 1H), 8.93 (m, 1H), 8.13 (d, 1H), 7.94 (s, 1H) 7.79 (d, 1H), 7.41 (dd, 1H), 6.88 (q, 1H), 2.76 (s, 3H), 2.37 (d, 3H). LCMS (method B): [MH]+=337, tR=2.21 min.

Quellen und Nachweise

ORD-Eintrag
ord-af339235733e40798c032325a933c498
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08497368B2

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