Acetyl chloride → 1-(3-Hydroxypiperidin-1-yl)ethan-1-one

Temperatur

-78 °C

3-Hydroxypiperidine (3.0 g, 30.0 mmol) was dissolved in THF (40 mL) and methylene chloride (40 mL). Triethylamine (7.47 g, 74.0 mmol) was added. The mixture was cooled to −78° C. and acetyl chloride (2.35 g, 30.0 mmol) was added drop wise. The mixture was warmed to r.t. and stirred under nitrogen for 1 about an hour. The solvents were removed under reduced pressure, and the resulting oil was purified using silica chromatography (2% methanol in ethyl acetate) to afford the title compound (3.57 g, 83%) as an oil.

1. temperatureThe mixture was warmed to r.t.
2. customThe solvents were removed under reduced pressure
3. customthe resulting oil was purified

ORD-Eintrag

ord-ee7f708a522c4e49b678cf3f9f315113

Quelldatensatz

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07186715B2