4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

HRID 45653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 45653
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].C(N(CC)CC)C.[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=1[CH2:27][NH:28][CH3:29]>O1CCOCC1>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:28]([CH2:27][C:21]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:20]=2[Cl:19])[CH3:29])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 74544-Bromophenacyl bromideHCID 8471TriethylamineHCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-

Produkt 1

HCID 223868281-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

Into a 250-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-bromo-1-(4-bromophenyl)ethanone (9.3 g, 33.45 mmol, 1.00 equiv) in dioxane (100 mL), triethylamine (5.0 g, 1.50 equiv), and (2,4-dichlorophenyl)-N-methylmethanamine (6.4 g, 33.68 mmol, 1.00 equiv). The resulting solution was stirred for 2 h at 25° C. The solids were filtered out. The filtrate was used for next step directly.

Aufarbeitung

  1. customInto a 250-mL 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. filtrationThe solids were filtered out

Quellen und Nachweise

ORD-Eintrag
ord-bcbc59806f7f4a2abcfb0732df48476e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541448B2

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