4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester → Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide

Beteiligte Stoffe

Reaktionsschritte

A solution of (e) (6.0 g, 14.3 mmol) in ethanol/ethyl acetate (150 ml/150 ml) was hydrogenated over 10% Pd/charcoal (5 g) for 1.5 hours. Filtration, washing with ethanol (400 ml) and evaporation of the filtrate gave a white solid (2.4 g, 59%).

Herkunft & Nachweise