1-(2-benzyloxyethyl)-4-[(4-ethylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-methyl-1H-pyrazole → HCID 69134411, Verbindung

HRID 457518

Reaktionsgleichung

Reaktionsgleichung von HRID 457518
C([O:8][CH2:9][CH2:10][N:11]1[C:15]([CH3:16])=[C:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH3:25])=[CH:20][CH:19]=2)[C:13]([O:26][C@@H:27]2[O:35][C@H:34]([CH2:36][OH:37])[C@@H:32]([OH:33])[C@H:30]([OH:31])[C@H:28]2[OH:29])=[N:12]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH2:24]([C:21]1[CH:20]=[CH:19][C:18]([CH2:17][C:14]2[C:13]([O:26][C@@H:27]3[O:35][C@H:34]([CH2:36][OH:37])[C@@H:32]([OH:33])[C@H:30]([OH:31])[C@H:28]3[OH:29])=[N:12][N:11]([CH2:10][CH2:9][OH:8])[C:15]=2[CH3:16])=[CH:23][CH:22]=1)[CH3:25]

Komponenten

4

Edukt 1

HCID 691337331-(2-benzyloxyethyl)-4-[(4-ethylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-methyl-1H-pyrazole

Produkt 1

HCID 69134411HCID 69134411, VerbindungAusbeute 111,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(2-benzyloxyethyl)-4-[(4-ethylphenyl)methyl]-3-(β-D-glucopyranosyloxy)-5-methyl-1H-pyrazole (0.012 g) in ethanol (2 mL) was added a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred at room temperature under a hydrogen atmosphere for 30 minutes. Insoluble materials were removed by filtration, and the solvent was removed under reduced pressure to give 4-[(4-ethylphenyl)methyl]-3-(β-D-glucopyranosyloxy)-1-(2-hydroxyethyl)-5-methyl-1H-pyrazole (0.011 g).

Aufarbeitung

  1. customInsoluble materials were removed by filtration
  2. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-69e7f10912ad4e2bab8da22c9d32e624
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189702B2

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