Methyl 2-(2-chloroethoxy)benzoate → HCID 17964344, Verbindung

HRID 457786

Reaktionsgleichung

Reaktionsgleichung von HRID 457786
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[C:16]([CH:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)=[CH:15]3)=[CH:9][C:4]=2[O:3][CH2:2]1.C[O:30][C:31](=[O:42])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[O:38][CH2:39][CH2:40]Cl>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[C:16]([CH:23]4[CH2:28][CH2:27][N:26]([CH2:40][CH2:39][O:38][C:33]5[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=5[C:31]([OH:42])=[O:30])[CH2:25][CH2:24]4)=[CH:15]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 17964363HCID 17964363, Verbindung

Produkt 1

HCID 17964344HCID 17964344, Verbindung

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part D), starting with 8.1 mmol of 1-[3-(benzo[1,3]dioxol-5-yloxy)-propyl]-3-piperidin-4-yl-1H-indole and 2.3 g (11 mmol) of of 2-(2-chloro-ethoxy)-benzoic acid methyl ester. After the standard work-up, 2.68 g of the corresponding acid was obtained. The crude mixture was purified by flash chromatography over silica gel affording 1.15 g (26% of yield) of the expected acid.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-e5e1cbc0df824c0db9432a878b3ad38e
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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