2-(2-Bromoethyl)-1,3-dioxolane → 4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-6-fluoro-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester

HRID 457795Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457795
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[CH2:23][CH2:24][CH:25]1[O:29][CH2:28][CH2:27][O:26]1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[N:14]([CH2:23][CH2:24][CH:25]3[O:29][CH2:28][CH2:27][O:26]3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 877762-(2-Bromoethyl)-1,3-dioxolaneHCID 113237384-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester

Produkt 1

HCID 694118344-[1-(2-[1,3]dioxolan-2-yl-ethyl)-6-fluoro-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl esterAusbeute 117,7 %

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.37 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.081 g (0.45 mmol) of 2-(2-bromo-ethyl)-[1,3]dioxolane. 0.170 g (quantitative yield) of 4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-6-fluoro-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-2ec8da7690854edf97db0d4c445ab0ca
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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