methyl 2-{2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-benzoate → 2-(2-{4-[1-(tetrahydro-furan-3-ylmethyl)-1H-indol-3-yl)-piperidin-1-yl}-ethoxy)-benzoic Acid

HRID 457810

Reaktionsgleichung

Reaktionsgleichung von HRID 457810
C[O:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1.CS(O[CH2:34][CH:35]1[CH2:39][CH2:38][O:37][CH2:36]1)(=O)=O>>[O:37]1[CH2:38][CH2:39][CH:35]([CH2:34][N:21]2[C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([CH:16]3[CH2:17][CH2:18][N:13]([CH2:12][CH2:11][O:10][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[C:3]([OH:2])=[O:28])[CH2:14][CH2:15]3)=[CH:20]2)[CH2:36]1

Komponenten

3

Edukt 2

HCID 11440344methyl 2-{2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-benzoateHCID 22273010(Tetrahydrofuran-3-yl)methyl methanesulfonate

Produkt 1

HCID 101386732-(2-{4-[1-(tetrahydro-furan-3-ylmethyl)-1H-indol-3-yl)-piperidin-1-yl}-ethoxy)-benzoic Acid

Versuchsvorschrift

This compound was prepared following the procedure described in example 1 (part E) starting with 0.1 g (0.26 mmol) of 2-{2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-benzoic acid methyl ester and 0.067 g (0.37 mmol) of freshly prepared tetrahydro-furan-3-ylmethyl methanesulfonate. After standard purification, 0.045 g (39% of yield) of the expected acid were obtained.

Aufarbeitung

  1. customThis compound was prepared
  2. customAfter standard purification, 0.045 g (39% of yield) of the expected acid
  3. customwere obtained

Quellen und Nachweise

ORD-Eintrag
ord-fddf8f7659664d49accf6d1111ea3921
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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