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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 457812Erstellt: 27. Oktober 2026

3-(4-Piperidinyl)-1H-indole → 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester

https://huagongshe.com/reaction/457812

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt3-(4-Piperidinyl)-1H-indoleHCID 702235—
EduktEthyl 2-(bromomethyl)pyridine-3-carboxylateHCID 825758—
Produkt2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl esterHCID 6941177992,4%

Reaktionsschritte

This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.5 mmol) of 3-piperidin-4-yl-1H-indole and 0.65 g (3.25 mmol) of 2-bromomethyl-nicotinic acid ethyl ester. After the standard purification, 0.84 g (92% of yield) of 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester were obtained.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07189741B2
Quelldatensatzuspto-grants-2007_03
ORD IDord-85e4af361a44410c8e77b8e15f557960
Quellennotizuspto-grants-2007_03