3-(Chloromethyl)pyridine hydrochloride → 2-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic Acid

HRID 457813

Reaktionsgleichung

Reaktionsgleichung von HRID 457813
C([O:3][C:4](=[O:27])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][C:6]=1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][CH:19]=2)[CH2:14][CH2:13]1)C.Cl.Cl[CH2:30][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1>>[N:33]1[CH:34]=[CH:35][CH:36]=[C:31]([CH2:30][N:20]2[C:21]3[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:18]([CH:15]3[CH2:14][CH2:13][N:12]([CH2:11][C:6]4[N:7]=[CH:8][CH:9]=[CH:10][C:5]=4[C:4]([OH:3])=[O:27])[CH2:17][CH2:16]3)=[CH:19]2)[CH:32]=1

Komponenten

3

Edukt 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 694117792-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester

Produkt 1

HCID 101595162-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic Acid

Versuchsvorschrift

This compound was prepared following the procedure described in example 1 (part E) starting with 0.76 g (0.21 mmol) of 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester and 0.04 g (0.25 mmol) of 3-chloromethyl-pyridine hydrochloride. After standard purification, 0.040 g (45% of yield) of the expected acid were obtained.

Aufarbeitung

  1. customThis compound was prepared
  2. customAfter standard purification, 0.040 g (45% of yield) of the expected acid
  3. customwere obtained

Quellen und Nachweise

ORD-Eintrag
ord-d806986ba8bd4db58d3712c538a6cf22
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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