HCID 17964359, Verbindung → 5-{4-[1-(2-[1,4]dioxan-2-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-2-methoxy-benzoic Acid

HRID 457819Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457819
[O:1]1[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[CH:10]1.C([O:26][C:27](=[O:38])[C:28]1[CH:33]=[C:32]([CH2:34]Br)[CH:31]=[CH:30][C:29]=1[O:36][CH3:37])C>>[O:1]1[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:34][C:32]3[CH:31]=[CH:30][C:29]([O:36][CH3:37])=[C:28]([CH:33]=3)[C:27]([OH:38])=[O:26])[CH2:20][CH2:19]2)=[CH:10]1

Komponenten

3

Edukt 2

HCID 17964359HCID 17964359, VerbindungHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Produkt 1

HCID 101627285-{4-[1-(2-[1,4]dioxan-2-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-2-methoxy-benzoic Acid

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part D) starting with 0.06 g (0.19 mmol) of 1-(2-[1,4]dioxan-2-yl-ethyl)-3-piperidin-4-yl-1H-indole and 0.071 g (0.26 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard purification, 0.019 g (65% of yield) were obtained.

Aufarbeitung

  1. customThis compound was prepared
  2. customAfter standard purification
  3. custom0.019 g (65% of yield)
  4. customwere obtained

Quellen und Nachweise

ORD-Eintrag
ord-76fd70cbd6dd45beadb426ecccc06269
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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