3-piperidin-4-yl-1-thiophen-2-ylmethyl-1H-indole → 2-methoxy-5-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]benzoic acid

HRID 457821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457821
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[CH:8]=2)[CH2:3][CH2:2]1.C([O:24][C:25](=[O:36])[C:26]1[CH:31]=[C:30]([CH2:32]Br)[CH:29]=[CH:28][C:27]=1[O:34][CH3:35])C>>[CH3:35][O:34][C:27]1[CH:28]=[CH:29][C:30]([CH2:32][N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[N:9]([CH2:16][C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)[CH:8]=3)[CH2:3][CH2:2]2)=[CH:31][C:26]=1[C:25]([OH:36])=[O:24]

Komponenten

3

Edukt 2

HCID 111506353-piperidin-4-yl-1-thiophen-2-ylmethyl-1H-indoleHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Produkt 1

HCID 102265012-methoxy-5-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]benzoic acid

Versuchsvorschrift

This compound was prepared following the procedure described in example 25 (part C) starting with 1.90 g (0.065 mol) of 3-piperidin-4-yl-1-thiophen-2-ylmethyl-1H-indole and 1.92 (0.071 mol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard purification and recrystallization with ethanol, 1.2 g (40% of yield) of the expected acid.

Aufarbeitung

  1. customThis compound was prepared
  2. customAfter standard purification and recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-06ca7ec20b35463a90bc3f7db698ea8d
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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