3-piperidin-4-yl-1-(2-thiophen-3-yl-ethyl)-1H-indole → 2-methoxy-5-{4-[1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic Acid

HRID 457824Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457824
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][CH2:17][C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)[CH:8]=2)[CH2:3][CH2:2]1.C([O:25][C:26](=[O:37])[C:27]1[CH:32]=[C:31]([CH2:33]Br)[CH:30]=[CH:29][C:28]=1[O:35][CH3:36])C>>[CH3:36][O:35][C:28]1[CH:29]=[CH:30][C:31]([CH2:33][N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[N:9]([CH2:16][CH2:17][C:18]4[CH:22]=[CH:21][S:20][CH:19]=4)[CH:8]=3)[CH2:3][CH2:2]2)=[CH:32][C:27]=1[C:26]([OH:37])=[O:25]

Komponenten

3

Edukt 2

HCID 179643093-piperidin-4-yl-1-(2-thiophen-3-yl-ethyl)-1H-indoleHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Produkt 1

HCID 102273272-methoxy-5-{4-[1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic Acid

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part D) starting with 1 g (3.2 mmol) of 3-piperidin-4-yl-1-(2-thiophen-3-yl-ethyl)-1H-indole and 1.15 g (4.2 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard work-up and purification, 1.16 g (76% of yield) of the expected acid were obtained.

Aufarbeitung

  1. customThis compound was prepared
  2. customAfter standard work-up and purification, 1.16 g (76% of yield) of the expected acid
  3. customwere obtained

Quellen und Nachweise

ORD-Eintrag
ord-04e66e8a14a14beebe6b643feec48f00
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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